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Incorporating Microbial Pilin-Based Nanowires into a Water-Stable Electronic Polymer Composite

Sonawane, J. M.; Chia, E.; Ueki, T.; Greener, J.; Nonnenmann, S. S.; Yao, J.; Lovley, D. R.

2024-06-13 bioengineering
10.1101/2024.06.11.598525 bioRxiv
Show abstract

Electrically conductive protein nanowires (e-PNs), microbially produced from a pilin monomer, are a novel, sustainable electronic material that can be genetically tailored for specific functions. e-PNs, expressed with Escherichia coli grown on the biodiesel byproduct glycerol, and mixed with polyvinyl butyral yielded a transparent, electrically conductive water-stable composite.Composite conductivity was adjusted by modifying the e-PN concentration or incorporating e-PNs genetically tuned for different conductivities. Electronic devices in which composites were the sensor component differentially responded to dissolved ammonia over a wide concentration range (1{micro}M-1M). Genetically modifying e-PNs to display an ammonia-binding peptide on their outer surface increased the sensor response to ammonia 10-fold. These results, coupled with the flexibility to design peptides for specific binding of diverse analytes, demonstrate that sustainably produced e-PNs offer the possibility of incorporating multiple sensor components, each specifically designed to detect different analytes with high sensitivity and selectivity, within one small sensor device.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.