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Meta TCT: Towards Interpretable Treatment Effects in Clinical Trials for Progressive Diseases

2024-06-03 epidemiology Title + abstract only
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In progressive diseases, like Alzheimers disease, treatments that slow progression should start early in the disease course to longer maintain higher levels of functioning. In corresponding clinical trials, the treatment effect is usually expressed in terms of mean differences on a clinical scale. Early in the disease course, however, treatment effects expressed on a clinical scale are often small but may nonetheless correspond to an important slowing of disease progression. This complicates the...

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