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Leveraging haplotype information in heritability estimation and polygenic prediction

2024-05-01 genetic and genomic medicine Title + abstract only
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Polygenic prediction has yet to make a major clinical breakthrough in precision medicine and psychiatry, where the application of polygenic risk scores are expected to improve clinical decision-making. Most widely used approaches for estimating polygenic risk scores are based on summary statistics from external large-scale genome-wide association studies, which relies on assumptions of matching data distributions. This may hinder the impact of polygenic risk scores in modern diverse populations ...

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