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RESIST ACINETO test for the rapid detection of NDM and OXA acquired carbapenemases directly from blood culture in Acinetobacter species

Potron, A.; Daniel, M.; Bay, M.; Choulet, P.; Garrigos, T.; Sababadichetty, L.; Belmonte, O.; Fournier, D.; Jeannot, K.; Miltgen, G.

2024-04-19 infectious diseases
10.1101/2024.04.18.24302391 medRxiv
Show abstract

The immunochromatographic assay RESIST ACINETO (Coris BioConcept) was evaluated on a collection of 121 Acinetobacter spp. clinical isolates, including 104 carbapenemase producers. The strains producing carbapenemases OXA-23, -40, -58, or/and NDM were accurately detected from bacterial cultures and directly from blood cultures, with the exception of an OXA-23/NDM-1-positive A. radioresistens isolate (only detected through standard culture). The performance of the RESIST ACINETO test was excellent (sensitivity 99%, specificity 100%) on this collection of isolates.

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