Design of a sequestration-based network with tunable pulsing dynamics
Nakamura, E.; Cuba Samaniego, C.; Blanchini, F.; Giordano, G.; Franco, E.
Show abstract
Incoherent feedforward networks exhibit the ability to generate temporal pulse behavior. However, exerting control over specific dynamic properties, such as amplitude and rise time, poses a challenge and is intricately tied to the networks implementation. In this study, we focus on analyzing sequestration-based networks capable of exhibiting pulse behavior. By employing time-scale separation in the fast sequestration regime, we approximate the temporal dynamics of these networks. This approach allows us to establish a mapping that elucidates the impact of varying the kinetic rates and pulse specifications, including amplitude and rise time. Furthermore, we introduce a positive feedback mechanism to regulate the amplitude of the pulsing response.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization. 96%
- Excitable dynamics in a molecularly-explicit model of cell motility: Mixed-mode oscillations and beyond 96%
- Population dynamics of multi-host communities attacked by a common parasitoid 95%
Similar papers in this journal
- An amplified derepression controller with multisite inhibition and positive feedback 96%
- Coherent feedback leads to robust background compensation in oscillatory and non-oscillatory homeostats 96%
- Background compensation revisited: Conserved phase response curves in frequency controlled homeostats with coherent feedback 96%
Similar papers in this journal
- Robust Cortical Criticality and Diverse Neural Network Dynamics Resulting from Functional Specification 96%
- Maximizing cooperation in the prisoner's dilemma evolutionary game via optimal control 96%
- Foci, waves, excitability : self-organization of phase waves in a model of asymmetrically coupled embryonic oscillators 96%
Similar papers in this journal
- A generic systems-theoretic approach to identify biological networks capable of adaptation 96%
- Multiplexing rhythmic information by spike timing dependent plasticity 96%
- Reliable ligand discrimination in stochastic multistep kinetic proofreading: First passage time vs. product counting strategies 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.