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Examining the association between the FTO gene and neuroticism reveals indirect effects on subjective well-being and problematic alcohol use
2024-02-21
addiction medicine
Title + abstract only
View on medRxiv
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Associations between the fat mass and obesity-associated (FTO) gene and obesity are well-established. However, recent studies have linked FTO to addiction phenotypes and dopaminergic signaling, thus suggesting broader psychiatric implications. We explored this assumption by conducting a phenome-wide association study (PheWAS) across 4,756 genome-wide association studies (GWASs), identifying 26 psychiatric traits associated with FTO at the multiple-corrected significance level. These traits clust...
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