Peptidoform analysis of IP-MS data allows detection of differentially present bait proteoforms
Sdelci, S.; Sdelci, S.; Kourtis, S.; Cianferoni, D.; Serrano, L.
Show abstract
While it is recognised that protein functions are determined by their proteoform state, such as mutations and post-translational modifications, methods to determine their differential abundance between conditions are limited. Here, we present a novel workflow for classical immunoprecipitation coupled to mass spectrometry (IP-MS) data that focuses on identifying differential peptidoforms of the bait protein between conditions, providing additional information about protein function.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Hybrid-DIA: Intelligent Data Acquisition for Simultaneous Targeted and Discovery Phosphoproteomics in Single Spheroids 97%
- MSFragger-DDA+ Enhances Peptide Identification Sensitivity with Full Isolation Window Search 96%
- Systematic detection of functional proteoform groups from bottom-up proteomic datasets 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.