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Titin-Truncating variants Predispose to Dilated Cardiomyopathy in Diverse Populations

2024-01-17 cardiovascular medicine Title + abstract only
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ImportanceThe effect of high percentage spliced in (hiPSI) TTN truncating variants (TTNtvs) on risk of dilated cardiomyopathy (DCM) has historically been studied among population subgroups defined by genetic similarity to European reference populations. This has raised questions about the effect of TTNtvs in diverse populations, especially among individuals genetically similar to African reference populations. ObjectiveTo determine the effect of TTNtvs on risk of DCM in diverse population as me...

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