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Development of a PROTAC Targeting Chk1

Chowdhury, S. R.; Chuong, P.; Mgbemena, V. E.; Statsyuk, A. V.

2024-01-01 cell biology
10.1101/2023.12.30.573733 bioRxiv
Show abstract

A series of Chk1 degraders were designed and synthesized. The degraders were developed through the conjugation of a promiscuous kinase binder and thalidomide. One of the degraders PROTAC-2 was able to decrease Chk1 levels in a concentration-dependent manner in A375 cells. The developed probes can be useful for the development of selective and more potent Chk1 degraders.

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