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Emergence and predominance of novel influenza A (H3N2) subclade (3C.2a1b.2a.2a.3a.1) in Kenya and globally in 2023

Morobe, J. M.; Moraa, E.; Lambisia, A. W.; Mutunga, M.; Kiage, B.; Katama, E. N.; Makori, T. O.; Nyiro, J.; Ndwiga, L.; Nyagwange, J.; Sande, C.; Ochola-Oyier, L. I.; Holmes, E. C.; Nokes, J.; Githinji, G.; Agoti, C. N.

2023-12-17 infectious diseases
10.1101/2023.12.15.23299920 medRxiv
Show abstract

We report emergence and predominance of the influenza A (H3N2) subclade 3C.2a1b.2a.2a.3a.1 in Kenya similar to the global clade in 2023. The Kenyan 3C.2a1b.2a.2a.3a.1 viruses have >15 amino acid differences in the HA and NA proteins relative to 2023/24 WHO recommended Northern/Southern Hemisphere influenza vaccine strains.

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