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Increased blood brain barrier leakage in schizophrenia spectrum disorders compared to healthy controls in dynamic contrast enhanced magnetic resonance imaging

2023-12-13 psychiatry and clinical psychology Title + abstract only
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BackgroundThere is growing evidence for inflammatory mechanisms in schizophrenia spectrum disorders (SSD) that have been associated with blood-brain barrier (BBB) disruption. Previous studies investigating the BBB in SSD focused on cerebrospinal fluid (CSF) markers, that cannot adequately assess BBB integrity. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) represents a sensitive method for investigating subtle barrier breakdown in vivo. So far, only one pilot study has investigat...

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