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Exploring the neuronal and systemic physiological contributions to spontaneous cerebral fluctuations - Insights from functional MRI in The Maastricht Study
2023-12-08
radiology and imaging
Title + abstract only
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ObjectiveFunctional MRI (fMRI) is sensitive to changes in the blood oxygen level-dependent (BOLD) signal, which originates from neurovascular coupling, the mechanism that links neuronal activity to changes in cerebral blood flow. Isolating the native spontaneous neuronal fluctuations from the BOLD signal of the resting-state is challenging, as the signal induced by neuronal activity represents only a small part of this signal. Furthermore, many other non-neuronal (systemic) oscillations contribu...
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