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Using digital spatial profiling to analyse onco-immune-related gene expression within oropharyngeal tumours in relation to HPV and p16 status

2023-11-17 oncology Title + abstract only
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Human Papilloma virus (HPV)-mediated oropharyngeal cancer (OPC) has significantly better prognosis compared with HPV-negative, stimulating interest in treatment de-intensification approaches to reduce long-term sequelae. Routine clinical testing frequently utilises immunohistochemistry to detect upregulation of p16 protein as a surrogate marker of HPV-mediation. However, this does not detect discordant HPV+/p16-cases and incorrectly assigns HPV-/p16+ cases, which, given their inferior prognosis ...

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