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MaSk-LMM: A Matrix Sketching Framework for Linear Mixed Models in Association Studies

2023-11-13 genetic and genomic medicine Title + abstract only
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Linear mixed models (LMMs) have been widely used in genome-wide association studies (GWAS) to control for population stratification and cryptic relatedness. Unfortunately, estimating LMM parameters is computationally expensive, necessitating large-scale matrix operations to build the genetic relatedness matrix (GRM). Over the past 25 years, Randomized Linear Algebra has provided alternative approaches to such matrix operations by leveraging matrix sketching, which often results in provably accur...

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