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Aβ-affine bifunctional copper chelators capable of Aβ-induced oxidative stress reduction and amyloid disaggregation

Krasnovskaya, O. O.; Abramchuk, D.; Vaneev, A.; Gorelkin, P.; Abakumov, M.; Timoshenko, R.; Chmelyuk, N.; Vadehina, V.; Kuanaeva, R.; Dubrovin, E. V.; Kolmogorov, V.; Beloglazkina, E. K.; Erofeev, A. S.

2023-10-13 pharmacology and toxicology
10.1101/2023.10.10.561649 bioRxiv
Show abstract

Alz-5 acts as a bifunctional chelator that can interact with various A{beta} aggregates and reduce their neurotoxicity. Single-cell ROS measurements provided by Pt-nanoelectrode technique revealed a significant antioxidant properties of Alz-5 in A{beta}42 - affected SH-SY5Y cell. AFM data obtained on A{beta}42 fibrils clearly indicate an anti-aggregating property of Alz-5. Youngs modulus mapping on living SH-SY5Y cells revealed an ability of Alz-5 to decrease cell rigidity in A{beta}42 - affected SH-SY5Y cells.

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