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Benefit-Risk Assessment of Medical Products Using Bayesian Multi-Criteria Augmented Decision Analysis (MCADA) for Clinical Development

2023-09-02 health informatics Title + abstract only
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Multi-criteria decision analysis (MCDA) is a benefit-risk assessment tool that evaluates multiple competing benefit and risk endpoints simultaneously. MCDA has the potential to aid sponsors in making effective and informed go/no-go decisions for clinical development programs. MCDA involves assigning weights to benefit and risk endpoints based on their relative importance (i.e., utility weight) and using them to compute a single utility score that represents the overall benefit-risk profile of th...

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