Earliest observation of the tetracycline destructase tet(X3)
Grenier, F.; Levesque, S.; Rodrigue, S.; Haraoui, L.-P.
Show abstract
Tigecycline is an antibiotic of last resort for infections with carbapenem-resistant Acinetobacter baumannii. Plasmids harboring variants of the tetracycline destructase tet(X) promote rising tigecycline resistance rates. We report the earliest observation of tet(X3) in a clinical strain predating tigecyclines commercialization, suggesting selective pressures other than tigecycline contributed to its emergence.
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