A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes in situ
Tao, A. J.; Jiang, J.; Gadbois, G. E.; Goyal, P.; Boyle, B. T.; Mumby, E. J.; Myers, S. A.; English, J. G.; Ferguson, F. M.
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Unbiased chemical biology strategies for direct readout of protein interactome remodelling by small molecules provide advantages over target-focused approaches, including the ability to detect previously unknown targets, and the inclusion of chemical off-compete controls leading to high-confidence identifications. We describe the BioTAC system, a small-molecule guided proximity labelling platform, to rapidly identify both direct and complexed small molecule binding proteins. The BioTAC system overcomes a limitation of current approaches, and supports identification of both inhibitor bound and molecular glue bound complexes.
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