Biocompatible hydrogel electrodeposition enables the simultaneous preparation of multi-microinterfaces for ligand bioconjugation and multiplexed electrochemical detection
Juska, V. B.; Moukri, N.; Estrela, P.; Maxwell, G. D.; Hendricks, S.; Santillan-Urquiza, E.; O'Brien, B.; Patella, B.; Inguanta, R.; O'riordan, A.
Show abstract
Affinity based electrochemical biosensing systems with integrated miniaturised interfaces has enabled key advancement toward rapid, sensitive, precise and deployable detection platforms. Manufacturing silicon micro/nano devices for biology interface has been a highly promising platform to design and develop electrochemical sensors for the detection of very low concentrations of the target molecules. However, the biofouling challenge of the biosensors when the surface is exposed to a complex matrix such as blood, serum, milk, has been a road blocker. Here we introduce a simple, rapid formation of an anti-biofouling coating onto several electroactive surface areas present on a single chip simultaneously. Using such a multiplexed surface, we were able to investigate the optimum working conditions on-chip. Concentrating on two individual bioassay platforms for stress biomarkers, haptoglobin and cortisol, we demonstrate the broad applicability of the developed universal platform with excellent performance in bovine serum and correlation with conventional ELISA using milk samples.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Electrochemical detection of myeloperoxidase (MPO) in blood plasma with surface-modified electroless nickel immersion gold (ENIG) printed circuit board (PCB) electrodes 98%
- Hollow ring-like flexible electrode architecture enabling subcellular multi-directional neural interfacing 96%
- Electrochemical DNA-based sensors for measuring cell-generated forces 96%
Similar papers in this journal
- Superhydrophobic Rotation-Chip for Computer-Vision Identification of Drug-Resistant Bacteria 95%
- SERS nanowire chip and machine learning enabled instant identification and classification of clinically relevant wild-type and antibiotic resistant bacteria at species and strain level 94%
- Plasmon-Coupled Photocapacitor Neuromodulators 94%
Similar papers in this journal
- Aerosol Jet Printing Enabled Dual-Function Electrochemical and Colorimetric Biosensor for SARS-CoV-2 Detection 97%
- Single-Walled Carbon Nanotube Probes for Protease Characterization Directly in Cell-Free Expression Reactions 95%
- Universal and naked-eye gene detection platform based on CRISPR/Cas12a/13a system 93%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.