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Statistical Analysis Plan: The Effect of Automated External Defibrillators for Cardiac Arrests in Private Homes

Andersen, L. W.; Holmberg, M. J.; Granfeldt, A.; Stakovic, N.; Hoeybye, M.; Folke, F.; Caulley, L.

2023-08-06 intensive care and critical care medicine
10.1101/2023.08.01.23293407 medRxiv
Show abstract

This document describes the statistical analysis plan for the study "The Effect of Automated External Defibrillators for Cardiac Arrests in Private Homes". This will be an observational study using prospectively collected data from the CARES registry in the United States. We will include patients with an out-of-hospital cardiac arrest in a private home. The exposure will be application of an AED and the primary outcome will be survival to hospital discharge. Assuming that there is no causal effect of AED application in those with a non-shockable rhythm, we will use a "difference-in-difference" approach to estimate the causal effect of AED application in those with a shockable rhythm.

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