Harnessing Gradients for Self-Assembly of Peptide-Based Nanocapsules: A Pathway to Advanced Drug Delivery Systems
Li, H.; Qian, X.; Mohanram, H.; Han, X.; Qi, H.; Zou, G.; Yuan, F.; Miserez, A. G. T.; Yang, Q.; Liu, T.; Gao, H.; Yu, J.
Show abstract
Biological systems often create materials with intricate structures to achieve specialized functions. In comparison, precise control of structures in man-made materials has been challenging. Here, we report a serendipitous discovery of insect cuticle peptides (ICPs) spontaneously forming nanocapsules through a single-step solvent exchange process, where the concentration gradient resulting from mixing of water and aceton drives the localization and self-assembly of the peptides into hollow nanocapsules. The underlying driving force is the intrinsic affinity of the peptides for a particular solvent concentration, while the diffusion of water and acetone creates a gradient interface that triggers peptide localization and self-assembly. This gradient-mediated self-assembly offers a transformative pathway towards next-generation drug delivery systems based on peptide nanocapsules.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Beyond the Triple Helix: Exploration of the Hierarchical Assembly Space of Collagen-like Peptides 96%
- Amino acids bind to phase-separating proteins and modulate biomolecular condensate stability and dynamics 96%
- Liquid condensate is a common state of proteins and polypeptides at the regime of high intermolecular interactions 96%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.