Introducing π-HelixNovo for practical large-scale de novo peptide sequencing
Yang, T.; Ling, T.; Sun, B.; Liang, Z.; Xu, F.; Huang, X.; Xie, L.; He, Y.; Li, L.; He, F.; Wang, Y.; Chang, C.
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De novo peptide sequencing is a promising approach for novel peptide discovery. We use a novel concept of complementary spectra to enhance ion information and propose a de novo sequencing model{pi} -HelixNovo based on Transformer architecture.{pi} -HelixNovo outperforms other state-of-the-art models and enhances the taxonomic resolution of gut metaproteome, taking a significant step forward in de novo sequencing.
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