PEP-Patch: Electrostatics in Protein-Protein Recognition, Specificity and Antibody Developability
Waibl, F.; Pomarici, N. D.; Hoerschinger, V. J.; Loeffler, J. R.; Deane, C.; Georges, G.; Kettenberger, H.; Fernandez-Quintero, M. L.; Liedl, K. R.
Show abstract
The electrostatic properties of proteins arise from the number and distribution of polar and charged residues. Due to their long-ranged nature, electrostatic interactions in proteins play a critical role in numerous processes, such as molecular recognition, protein solubility, viscosity, and antibody developability. Thus, characterizing and quantifying electrostatic properties of a protein is a pre-requisite for understanding these processes. Here, we present PEP-Patch, a tool to visualize and quantify the electrostatic potential on the protein surface and showcase its applicability to elucidate protease substrate specificity, antibody-antigen recognition and predict heparin column retention times of antibodies as an indicator of pharmacokinetics.
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