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Age-associated alterations in thalamocortical structural connectivity in psychosis-spectrum youths

2023-07-12 psychiatry and clinical psychology Title + abstract only
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ObjectivePsychotic symptoms typically emerge in adolescence when connections between the thalamus and cortex are still maturing. The extent to which thalamocortical connectivity differences observed in psychosis occur as a function of age-associated alterations is not fully understood. MethodsWe analyzed diffusion-weighted imaging data from 1254 participants 8-23 years old (typically developing youth: N=626, psychosis-spectrum youth: N=329, other psychopathology: N=299) from the Philadelphia Ne...

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