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New distance measure for comparing protein using cellular automata image

Ferreira de Souza, L.; B. de B. Pereira, H.; M. da Rocha Filho, T.; A. S. Machado, B.; A. Moret, M.

2023-06-21 bioinformatics
10.1101/2023.06.16.545334 bioRxiv
Show abstract

One of the first steps in protein sequence analysis is comparing sequences to look for similarities. We propose an information theoretical distance to compare cellular automata representing protein sequences, and determine similarities. Our approach relies in a stationary Hamming distance for the evolution of the automata according to a properly chosen rule, and to build a pairwise similarity matrix and determine common ancestors among different species in a simpler and less computationally demanding computer codes when compared to other methods.

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