Gene regulatory programs in the life history of Salpingoeca rosetta
Fumagalli, M. R.; Zapperi, S.; La Porta, C. A. M.
Show abstract
The choanoflagellate Salpingoeca rosetta can differentiate into at least five morphologically and behaviorally distinct cell types during its lifetime, going from individual motile cells to linear and rosette-shaped colonies. Due to the capability to form colonies and its close relationship with Metazoa, this organism is considered a model for studying multicellular evolution. The gene regulatory programs underlying these transformations are, however, unknown. Here we analyze transcriptomic data obtained from Salpingoeca rosetta in different states to identify a core of genes associated with the formation of multicellular colonies. We then compare the results with other organisms which display simple forms of multicellularity, highlighting commonalities and differences.
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