Biomechanical Strain Responses in the Optic Nerve Head Region in Glaucoma Patients After Intraocular Pressure Lowering

ObjectiveTo measure strain values and their association with intraocular pressure (IOP) change across five posterior eye regions in glaucoma patients. DesignCohort study. ParticipantsGlaucoma patients who were imaged with optical coherence tomography (OCT) prior to and after laser suturelysis following trabeculectomy surgery (29 image pairs, 26 persons) InterventionNoninvasive imaging of the eye. Main OutcomesStrain values in eye regions. ResultsMean strains were lowest in the retina and highest in the prelaminar neural tissue (PLNT) for Emax,{Gamma} max, and Ezz. The values of Emax in the anterior lamina cribrosa (ALC) and sclera were significantly related (P=0.0094, linear regression). Higher axial strain (Ezz) was significantly associated with greater IOP decrease in the ALC, PLNT, and retina (P<0.05). Higher{Gamma} max and Emax strains were significantly associated with greater IOP decreases across all 5 eye regions. ALC and PLNT had negative median radial (Err) compliance, while sclera had positive Err compliance (P=0.017). Emax and{Gamma} max strains of the ALC were significantly and positively associated with these strains in the other 4 regions (P<0.005). Likewise, the Ezz of ALC had a significant positive relationship with the other 4 regions (P<0.05). ConclusionsRegional strains in the optic nerve head zone can be effectively measured using OCT and are related to the magnitude of IOP change. Strains were largest in PLNT and ALC and were smallest in retina. The sclera and choroid on average expand radially and circumferentially indicating a volume increase with IOP lowering.