Two artificial tears outbreak-associated cases of XDR Pseudomonas aeruginosa detected through whole genome sequencing-based surveillance
Sundermann, A. J.; Rangachar Srinivasa, V.; Mills, E. G.; Griffith, M. P.; Waggle, K. D.; Ayres, A. M.; Pless, L.; Snyder, G. M.; Harrison, L. H.; Van Tyne, D.
Show abstract
We describe two cases of XDR Pseudomonas aeruginosa infection caused by a strain of public health concern recently associated with a nationwide outbreak of contaminated artificial tears. Both cases were detected through database review of genomes in the Enhanced Detection System for Hospital-Associated Transmission (EDS-HAT), a routine genome sequencing-based surveillance program. We generated a high-quality reference genome for the outbreak strain from one of the case isolates from our center and examined the mobile elements encoding blaVIM-80 and blaGES-9 carbapenemases. We then used publicly available P. aeruginosa genomes to explore the genetic relatedness and antimicrobial resistance genes of the outbreak strain.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Risk Factor Analysis for Extended-Spectrum Beta-Lactamase Producing Enterobacterales Colonization or Infection: Evaluation of a Novel Approach to Assess Local Prevalence as a Risk Factor 95%
- Genomic epidemiologic assessment implicates prolonged silent carriage, virulence factors and transmission between staff and patients in a NICU outbreak of MRSA 93%
- First identification of SARS-CoV-2 Lambda (C.37) variant in Southern Brazil 89%
Similar papers in this journal
- Clinical implementation of routine whole-genome sequencing for hospital infection control of multi-drug resistant pathogens 94%
- Unsuspected clonal spread of Methicillin-resistant Staphylococcus aureus causing bloodstream infections in hospitalized adults detected using whole genome sequencing 93%
- Genome Sequencing Identifies Previously Unrecognized Klebsiella pneumoniae Outbreaks in Neonatal Intensive Care Units in the Philippines 93%
Similar papers in this journal
- Rapid nanopore metagenomic sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis 93%
- Clinical and genomic epidemiology of mcr - 9 -carrying carbapenem-resistant Enterobacterales isolates in Metropolitan Atlanta, 2012-2017 93%
- Antimicrobial Susceptibilities of Clinical Bacterial Isolates from Urinary Tract Infections to Fosfomycin and Comparator Antibiotics Determined by Agar Dilution Method and Automated Micro Broth Dilution 92%
Similar papers in this journal
- Salmonella Infantis, the emerging human multidrug resistant pathogen - a One Health perspective 92%
- Retrospective Study of Bacteremia Caused by Alistipes Species in Japan, 2016–2023 92%
- Carriage duration of carbapenemase-producing Enterobacteriaceae in a hospital cohort - implications for infection control measures 91%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.