mRNA challenge predicts brain cancer immunogenicity and response to checkpoint inhibitors
Castillo, P.; Ogando-Rivas, E.; Geffrard, H.; Pepe, A.; Liu, R.; Nguyen, D. T.; Pedro, D.; Zhang, D.; DeVries, A.; Qdaisat, S.; Karachi, A.; Rahman, M.; Weidert, F.; Milner, R.; Huang, J.; Ligon, J. A.; Silver, N.; Li, D.; Lee, J.-H.; Carrera-Justiz, S.; Mitchell, D. A.; Mendez-Gomez, H.; Sawyer, W. G.; Sayour, E. J.
Show abstract
To prospectively determine whether brain tumors will respond to immune checkpoint inhibitors (ICIs), we developed a novel mRNA vaccine as a viral mimic to elucidate cytokine release from brain cancer cells in vitro. Our results indicate that cytokine signatures following mRNA challenge differ substantially from ICI responsive versus non-responsive murine tumors. These findings allow for creation of a diagnostic assay to quickly assess brain tumor immunogenicity, allowing for informed treatment with ICI or lack thereof in poorly immunogenic settings.
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