BDNF, inflammatory and oxidative levels in treatment-naïve ADHD children treated with methylphenidate: An open cohort protocol.
de Lucca, M. S.; de Miranda, D. M.; Cardoso, S. A.; Tonon, L. L.; Ferreira, J. A.; Cabral, B. S.; Raimundo, C. K. O.
Show abstract
The attention-deficit hyperactivity disorder (ADHD) has a complex etiology, involving the interaction between biological, genetic, and environmental factors. The ADHD pathophysiology remains unknown even though there are hypotheses that inflammatory, hormonal, oxidative and neurotrophic factors are associated. This clinical trial aims to evaluate the contribution of brain derived neurotrophic factor (BDNF), inflammatory and oxidative levels before and after 12 and 24 weeks of methylphenidate use. MethodsPatients will be screened upon their entry into Child and Adolescent Psychiatry Teaching Outpatient Clinic of the Medical Course at the Federal University of Vicosa in Minas Gerais, Brazil. One hundred and fifty ADHD treatment-naive children of both sexes, between 6-14 years old, will be invited to participate, after the ADHD diagnosis by an experienced psychiatrist and the child fulfilling the inclusion criteria. Children and their caregivers will answer questionnaires regarding mental health and the children will undergo neuropsychological tests, physical, nutritional and activity assessment, in addition to blood sampling at baseline, 12 and 24 weeks of methylphenidate use respectively. DiscussionThis clinical trial intends to verify how the pharmacological treatment changes the plasma BDNF, inflammatory and oxidative levels in treatment-naive Brazilian children diagnosed for ADHD. Trial RegistrationSubmitted for registration on Brazilian Registry of Clinical Trials (ReBEC). Trial identifier: 13612 Registry name: Niveis de neurotrofina, perfil inflamatorio e oxidativo em criancas com TDAH tratadas com metilfenidato.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Association Study Of Six Candidate Genes With Major Depressive Disorder In The North-Western Population Of Pakistan 95%
- Sex- and age- dependent effect of pre-gestational chronic stress and mirtazapine treatment on neurobehavioral development of offspring 94%
- Characteristics of University Students Supported by Counseling Services: Analysis of psychological tests and pulse rate variability 94%
Similar papers in this journal
- Have the COVID-19 Pandemic and Lockdown Affected Children’s Mental Health in the Long Term? A Repeated Cross-Sectional Study 94%
- Psychiatric Manifestations and Associated Risk Factors among Hospitalized Patients with COVID-19 in Edo State, Nigeria 94%
- Early School Years follow up of the Asking Questions in Alcohol Longitudinal Study in Melbourne, Australia ( AQUA at 6 ): Cohort profile 93%
Similar papers in this journal
- Attitude towards Mental Help-Seeking, Motivation, and Economic Resources in Connection with Positive, Negative, and General Psychopathological Symptoms of Schizophrenia: A Pilot Study of a Psychoeducation Program 95%
- Responsivity of the striatal dopamine system to methylphenidate – a within-subject I-123-ß-CIT-SPECT study in children and adolescents with Attention-Deficit/Hyperactivity Disorder 94%
- Adolescents and adults with FOXP1 syndrome show high rates of anxiety and externalizing behaviors but not psychiatric decompensation or skill loss 94%
Similar papers in this journal
- Factors predicting serum clozapine levels in Middle Eastern patients: an observational study 94%
- Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder 94%
- Treatment provision for adults with ADHD during the COVID-19 pandemic: An exploratory study on patient and therapist experience with on-site sessions using face masks vs. telepsychiatric sessions 93%
Similar papers in this journal
- The recurrence of illness (ROI) index is a key factor in major depression that indicates increasing immune-linked neurotoxicity and vulnerability to suicidal behaviors. 95%
- Higher levels of serum IL-1β and TNF-α are associated with an increased probability of major depressive disorder 94%
- Global burden of mental health problems among children and adolescents during COVID-19 pandemic: A systematic umbrella review 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.