HIV Pharmacology Data Repository (PDR): Setting the New Information Sharing Standard for Pharmacokinetic Studies
Tompkins, L. A. R.; Kapeljushnik, O.; Hubal, R.; Khoei, A.; Dumond, J.; Kashuba, A. D.; Tropsha, A.; Cottrell, M. L.
Show abstract
Clinical therapeutics are becoming increasingly reliant on data science and computational data analytical tools to predict drug behavior in unobserved conditions or populations. These in silico approaches, collectively termed "pharmacometrics", derive biological meaning from the analysis of pooled drug concentration vs. time (CvT) datasets. However, the field lacks standardization for pharmacokinetic (PK) data description and sharing, instead requiring deep dives into the literature and expert data annotation for aggregate data mining. Here we introduce a minimum information sharing standard for PK studies composed of three categories (Intervention, System, and Effects) and implement this standard in the development of a web-based PK database: the HIV Pharmacology Data Repository (PDR). We demonstrate the utility of the HIV PDR by computational modeling of aggregated and curated CvT data extracted from the HIV PDR.
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