Elucidation of the Structures of β1- and β2-Transferrin Using Microprobe-Capture In-Emitter Elution and High-Resolution Mass Spectrometry

2023-01-30 pathology Title + abstract only

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BackgroundCerebrospinal fluid (CSF) leak is typically diagnosed by detecting a protein marker {beta}2-transferrin ({beta}2-Tf) in secretion samples. {beta}2-Tf and {beta}1-transferrin ({beta}1-Tf) are glycoforms of human transferrin (Tf). A novel affinity capture technique for sample preparation, called microprobe-capture in-emitter elution (MPIE), was incorporated with high-resolution mass spectrometry (HR-MS) to analyze the Tf glycoforms and elucidate the structures of {beta}1-Tf and {beta}2-T...

Elucidation of the Structures of β1- and β2-Transferrin Using Microprobe-Capture In-Emitter Elution and High-Resolution Mass Spectrometry

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