Evidence that SPIO Chain Formation is Essential for High-Resolution MPI
Colson, C.; Fung, K. L. B.; Bryan, J.; Tay, Z. W.; Fellows, B. D.; Sayuujya, C.; Kuo, R.; Chandrasekharan, P.; Conolly, S. M.
Show abstract
Magnetic Particle Imaging (MPI) is a noninvasive imaging modality that exploits the saturation properties of superparamagnetic iron oxide particles (SPIOs). A major thrust of MPI research aims to sharpen the magnetic resolution of biocompatible SPIOs, which will be crucial for affordable and safe clinical translation. We recently reported on a new class of MPI tracers --called superferromagnetic iron oxide nanoparticles (SFMIOs) -- which offer much sharper magnetic saturation curves. SFMIOs experimentally demonstrate 10-fold improvement in both resolution and sensitivity. However, superferromagnetism is a relatively unexplored branch of physics and the nanoscale physics and dynamics of SFMIOs remain a mystery. Here we show experimentally that chaining of SPIOs can explain SFMIOs boost in SNR and resolution. We show how concentration, viscosity, transmit amplitude, and pre-polarization time can all affect SPIO chain formation and SFMIO behavior. These experiments will inform strategies on SFMIO chemical synthesis as well as SFMIO data acquisition pulse sequences.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Integration and evaluation of magnetic stimulation in physiology setups 92%
- Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing 91%
- Cellular porosity in dentin exhibits complex network characteristics with spatio-temporal fluctuations 91%
Similar papers in this journal
- A Generalized Signal Model for Dual-Module Velocity-Selective Arterial Spin Labeling 93%
- Evaluation of a deuterated triarylmethyl spin probe for in vivo R2*-based EPR oximetric imaging with enhanced dynamic range 92%
- A Numerical Alternative to MR Thermometry for Safety Validation of Multi-Channel RF Transmit Coils 91%
Similar papers in this journal
- Quantum Magnetization Exchange through Transient Hydrogen Bond Matrix Defines Magnetic Resonance Signal Relaxation and Anisotropy in Central Nervous System 93%
- The sensitivity of magnetic particle imaging and fluorine-19 magnetic resonance imaging for cell tracking 93%
- Improved 7 Tesla Transmit Field Homogeneity with Reduced Electromagnetic Power Deposition Using Coupled Tic Tac Toe Antennas 92%
Similar papers in this journal
- Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics 89%
- Microvascular morphology affects radiotherapy outcomes: a computational study 89%
- Local Mean Suppression Filter for Effective Background Identification in Fluorescence Images 89%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.