Back

Systematic analysis and optimization of early warning signals for critical transitions

Proverbio, D.; Skupin, A.; Goncalves, J.

2022-11-04 systems biology
10.1101/2022.11.04.515178 bioRxiv
Show abstract

Abrupt shifts between alternative regimes occur in complex systems, from cell regulation to brain functions to ecosystems. Several model-free Early Warning Signals (EWS) have been proposed to detect impending transitions, but failure or poor performance in some systems have called for better investigation of their generic applicability. In particular, there are still ongoing debates whether such signals can be successfully extracted from data. In this work, we systematically investigate properties and performance of dynamical EWS in different deteriorating conditions, and we propose an optimised combination to trigger warnings as early as possible, eventually verified on experimental data. Our results explain discrepancies observed in the literature between warning signs extracted from simulated models and from real data, provide guidance for EWS selection based on desired systems and suggest an optimised composite indicator to alert for impending critical transitions. HighlightsO_LIHow to extract early warning signals (EWS) against critical transitions from data is still poorly understood C_LIO_LIA mathematical framework assesses and explains the performance of EWS in noisy deteriorating conditions C_LIO_LIComposite indicators are optimised to alert for impending shifts C_LIO_LIThe results are applicable to wide classes of systems, as shown with models and on empirical data. C_LI

Matching journals

The top 5 journals account for 50% of the predicted probability mass.

1
npj Systems Biology and Applications
99 papers in training set
Top 0.1%
22.6%
2
PLOS Computational Biology
1633 papers in training set
Top 2%
14.7%
3
Journal of Theoretical Biology
144 papers in training set
Top 0.2%
4.9%
4
Computational and Structural Biotechnology Journal
216 papers in training set
Top 0.8%
4.9%
5
Computers in Biology and Medicine
120 papers in training set
Top 0.7%
4.0%
50% of probability mass above
6
Journal of The Royal Society Interface
189 papers in training set
Top 1.0%
4.0%
7
PLOS ONE
4510 papers in training set
Top 39%
3.6%
8
Chaos, Solitons & Fractals
32 papers in training set
Top 0.6%
3.1%
9
Royal Society Open Science
193 papers in training set
Top 1%
2.4%
10
Ecological Modelling
24 papers in training set
Top 0.2%
2.1%
11
BMC Bioinformatics
383 papers in training set
Top 4%
2.1%
12
Scientific Reports
3102 papers in training set
Top 50%
2.1%
13
Bioinformatics
1061 papers in training set
Top 7%
1.8%
14
Briefings in Bioinformatics
326 papers in training set
Top 4%
1.7%
15
iScience
1063 papers in training set
Top 19%
1.3%
16
BioSystems
11 papers in training set
Top 0.2%
1.2%
17
The Journal of Chemical Physics
49 papers in training set
Top 0.3%
1.2%
18
Methods in Ecology and Evolution
160 papers in training set
Top 2%
0.7%
19
Journal of the Royal Society Interface
18 papers in training set
Top 0.1%
0.7%
20
IFAC-PapersOnLine
12 papers in training set
Top 0.1%
0.7%
21
International Journal of Molecular Sciences
453 papers in training set
Top 18%
0.6%
22
PeerJ
261 papers in training set
Top 17%
0.6%
23
Biosystems
18 papers in training set
Top 0.5%
0.6%
24
Biophysical Journal
545 papers in training set
Top 6%
0.6%