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Lung transcriptomics of radiologic emphysema reveal barrier function impairment and macrophage M1-M2 imbalance
2022-10-22
respiratory medicine
Title + abstract only
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RationaleWhile many studies have examined gene expression in lung tissue, the gene regulatory processes underlying emphysema are still not well understood. Finding efficient non-imaging screening methods and disease-modifying therapies has been challenging, but knowledge of the transcriptomic features of emphysema may help in this effort. ObjectivesOur goals were to identify emphysema-associated biological pathways through transcriptomic analysis of bulk lung tissue, to determine the lung cell ...
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