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The role of myosin contractility as a molecular determinant of traction force regulation

Ghosh, D.; Ghosh, S.; Chaudhuri, A.

2022-08-30 biophysics
10.1101/2022.08.30.505821 bioRxiv
Show abstract

Cells generate traction forces on the extracellular matrix to crawl forward. A complex molecular machinery is involved in the generation, transmission, and transduction of cellular forces inside and outside of cells. The molecular clutch hypothesis, with motors as rudimentary force generators, has been beneficial in modelling the distinctive biomechanical roles played by the components of this machinery. In this paper, we propose an analytical model that incorporates the active dynamics of myosin motors and establishes their roles in regulating the traction force in an experimentally accessible parameter space. As the parameters pertaining to molecular determinants are varied, we show that the system traverses between diverse states of stabilities - from decaying oscillations to self-sustaining limit cycles. The hallmarks of motor-clutch models like load-and-fail dynamics and shift in traction optima are successfully encapsulated. Modulating myosin activity in our model via different pathways exhibits striking shifts in optimal stiffness, providing excellent agreement with experiments and additional testable predictions.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.