Is acetazolamide a potential intervention for people with bipolar disorders? A scoping review protocol.
Strawbridge, R.; Orfanos, S.; Yalin, N.; Young, A. H.
Show abstract
Acetazolamide is a carbonic anhydrase inhibitor whose primary indication is to alleviate altitude sickness, but it is also used in the treatment of glaucoma, seizures and oedema. Although it has not been repurposed for psychiatric illnesses, acetazolamide has been advocated for its putative benefits in those with a bipolar disorder (BD). Because current treatment options for BD bring a variety of challenges, it is important to examine the current evidence to date in a formal synthesis. This article describes a protocol for a scoping review to do so, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR). PubMed, Embase and PsycInfo will be searched for all available publications focusing on the intervention acetazolamide for people with BD. This will include non-primary and primary research of any design, focusing on any outcome, in order to comprehensively bring together the work that has been undertaken to date on this topic. Relevant data from included articles will be subject to a narrative synthesis. It is anticipated that the results from the review will help to ascertain the potential for acetazolamide to benefit people with bipolar affective disorders in the future and aid the planning of future primary research to establish this.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Oral Ketamine for the Treatment of Depression: A randomized controlled trial and meta-analysis 93%
- Increased neurotoxicity due to activated immune-inflammatory and nitro-oxidative stress pathways in patients with suicide attempts: a systematic review and meta-analysis. 93%
- Multidimensional apathy: A simple and inclusive clinical marker of youth mental health—A longitudinal study 91%
Similar papers in this journal
- Side effect profile and comparative tolerability of newer generation antidepressants in the acute treatment of major depressive disorder in children and adolescents: protocol for a systematic review and network meta-analysis 95%
- Individual participant data systematic reviews with meta-analyses of psychotherapies for borderline personality disorder: A protocol 93%
- Global prevalence of antidepressant utilization in the community: A protocol for a systematic review 92%
Similar papers in this journal
- Latent subtypes of manic or irritable episode symptoms in two population-based cohorts 91%
- Prescribing of antipsychotics for people diagnosed with severe mental illness in UK primary care: A 20-year investigation of who receives treatment, with which agents, and at what doses 90%
- The impact of the COVID-19 pandemic on health service utilisation following self-harm: a systematic review 90%
Similar papers in this journal
- Single-session intervention with and without video support to prevent the worsening of emotional distress among healthcare workers during the SARS-CoV-2 pandemic: a randomized clinical trial 90%
- Quantifying Care, Qualifying Experiences: A Systematic Review of Measurement-Based Care in Psychiatry from Patient and Provider Perspectives 90%
- The development and validation of a prognostic model to predict relapse in adults with remitted depression in primary care: secondary analysis of pooled individual participant data from multiple studies 89%
Similar papers in this journal
- Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression: A protocol for a systematic review and meta-analysis 94%
- Interventions Promoting Recovery from Depression for Patients Transitioning from Outpatient Mental Health Services to Primary Care: Protocol for a Scoping Review 92%
- Pharmacotherapy, drug-drug interactions and potentially inappropriate medication in depressive disorders 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.