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Phenome-wide association network demonstrates close connection with individual disease trajectories from the HUNT study

2022-07-19 genetic and genomic medicine Title + abstract only
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BackgroundDisease networks offer a potential road map of connections between diseases. Several studies have created disease networks where diseases are connected either based on shared genes or Single Nucleotide Polymorphisms (SNP) associations. However, it is still unclear to which degree SNP-based networks map to empirical co-observed diseases within a different, general, adult study population spanning over a long time period. MethodsWe create a SNP-based disease network (PheNet) from a larg...

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