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Clinical symptoms, cognitive performance and cortical activity following mild traumatic brain injury (mTBI)

Coyle, H.; Bailey, N. W.; Ponsford, J.; Hoy, K.

2022-06-06 neurology
10.1101/2022.06.05.22275980 medRxiv
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ObjectiveTo investigate clinical symptoms, cognitive performance and cortical activity following mild traumatic brain injury (mTBI). MethodsThirty individuals in the sub-acute phase post mTBI and 28 healthy controls with no history of head injury were compared on clinical, cognitive and cortical activity measures. Measures of cortical activity included; resting state EEG, task related EEG and combined transcranial magnetic stimulation with electroencephalography (TMS-EEG). Primary analyses investigated clinical, cognitive and cortical activity differences between groups. Exploratory analyses investigated the relationships between these measures. ResultsAt 4 weeks post injury, mTBI participants exhibited significantly greater post concussive and clinical symptoms compared to controls; as well as reduced cognitive performance on verbal learning and working memory measures. mTBI participants demonstrated alterations in cortical activity while at rest and in response to stimulation with TMS. ConclusionsThe mTBI group demonstrated neurophysiological markers of altered excitatory and inhibitory processes which impact neural function. Further research is needed to explore the relationship between these pathophysiologies and clinical/cognitive symptoms in mTBI.

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