Emergence and Genomic Characterization of Multidrug resistant Candida auris in West Africa.
Oladele, R. O.; Uwanibe, J. N.; Olawoye, I. B.; Ettu, A.-W. O.; Happi, C.
Show abstract
Candida auris is an emerging multidrug-resistant fungal pathogen that has become a worldwide public health threat due to limitations of treatment options, difficulty in diagnosis, and its potential for clonal transmission. Antifungal suceptibility tests and next generation sequencing were carried out on cultured isolates. Bioinformatics analysis was done using variant calling methods and genome-wide short nucleotide polymorphism (SNP) based phylogeny. Here, we report the first four cases of C. auris infection and colonization reported in West Africa. A total of four isolates from four reported cases of candidemia were analyzed. Three patients had fungaemia, which led to fatal invasive infection and the last patient was a likely case of colonization. Of the four patients, two had mutations which conferred resistance to the antifungal azole group and other non-synonymous mutations in hotspot genes such as ERG2, ERG11 and FKS1. Isolates from these patients clustered to clades I and IV, which indicates more than one introduction of C.auris into Nigeria. The first report of C. auris in Nigeria and West Africa is of public health importance as this report will aid identification, surveillance and intervention of resistant drug resistant candidiasis in the region.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates from Egyptian Patients 96%
- Abrogation of pathogenic attributes in drug resistant Candida auris strains by farnesol 96%
- Molecular Characterization of invasive Enterobacteriaceae from Pediatric Patients in Central and Northwestern Nigeria 95%
Similar papers in this journal
- Molecular Epidemiology and Microbiological Characteristics of Cryptococcus gattii VGII isolates from China 97%
- The development of a novel diagnostic PCR for Madurella mycetomatis using a comparative genome approach 96%
- In Vitro Evidence to Support Amphotericin B and Flucytosine Combination Therapy for Talaromycosis 95%
Similar papers in this journal
- In vitro Evaluation of Antifungal Drug Combinations against Multidrug-resistant Candida auris isolates from New York Outbreak 96%
- Identification of novel mutations contributing to azole tolerance of Aspergillus fumigatus through in vitro exposure to tebuconazole 95%
- Burkholderia pseudomallei clinical isolates are highly susceptible in vitro to cefiderocol, a novel siderophore cephalosporin 94%
Similar papers in this journal
- Functional characterization of clinical isolates of the opportunistic fungal pathogen Aspergillus nidulans 94%
- Bisphosphonates synergistically enhance the antifungal activity of azoles in dermatophytes and other pathogenic molds 93%
- A Nanoemulsion as an Effective Treatment Against Human Pathogenic Fungi 93%
Similar papers in this journal
- CanID-PCR: A quick and low-cost PCR tool to identify Candida species on gDNA directly extracted from positive blood bottles 95%
- Distribution, Prevalence of Non-Tuberculous Mycobacteria in Hainan Island and Antibiotic Resistance of Mycobacterium abscessus 95%
- Differential growth rates and in vitro drug susceptibility to currently used drugs for multiple isolates of Naegleria fowleri 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.