Risk of myocarditis and pericarditis following COVID-19 vaccination in England and Wales
Ip, S.; Torabi, F.; Denaxas, S.; Akbari, A.; Abbasizanjani, H.; Knight, R.; Cooper, J. A.; Denholm, R.; Keene, S.; Bolton, T.; Hollings, S.; Omigi, E.; North, T.-L.; Karthikeyan Suseeladevi, A.; Di Angelantonio, E.; Khunti, K.; Sterne, J. A. C.; Sudlow, C.; Whiteley, W.; Wood, A.; Walker, V.; British Heart Foundation Data Science Centre (HDR UK) CVD-COVID-UK/COVID-IMPACT Consortium, ; UK Covid-19 Longitudinal Health and Wellbeing National Core Study, ; UK Covid-19 Data and Connectivity National Core Study,
Show abstract
We describe our analyses of data from over 49.7 million people in England, representing near-complete coverage of the relevant population, to assess the risk of myocarditis and pericarditis following BNT162b2 and ChAdOx1 COVID-19 vaccination. A self-controlled case series (SCCS) design has previously reported increased risk of myocarditis after first ChAdOx1, BNT162b2, and mRNA-1273 dose and after second doses of mRNA COVID-19 vaccines in England. Here, we use a cohort design to estimate hazard ratios for hospitalised or fatal myocarditis/pericarditis after first and second doses of BNT162b2 and ChAdOx1 vaccinations. SCCS and cohort designs are subject to different assumptions and biases and therefore provide the opportunity for triangulation of evidence. In contrast to the findings from the SCCS approach previously reported for England, we found evidence for lower incidence of hospitalised or fatal myocarditis/pericarditis after first ChAdOx1 and BNT162b2 vaccination, as well as little evidence to suggest higher incidence of these events after second dose of either vaccination.
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