Waning of Vaccine-Conferred Protection against SARS-CoV-2 Infection: Matched Case-Control Test-Negative Design Study in Two High-Risk Populations
Goldhaber-Fiebert, J. D.; Prince, L.; Chin, E. T.; Leidner, D.; Studdert, D. M.; Salomon, J. A.; Andrews, J. R.
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To distinguish waning of vaccine responses from differential variant protection, we performed a test-negative case-control analysis during a Delta variant-dominant period in Californias prisons. We found that infection odds increased each 28-day period post-vaccination, reaching 3.4-fold (residents) to 4.7-fold (staff) increased odds of infection after 180 days.
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