The voltage-gated Cav Ca2+ channel subunit α2δ-4 is required for locomotor behavior and sensorimotor gating in mice
Klomp, A.; Lee, A.; Omichi, R.; Iwasa, Y.; Smith, R.; Usachev, Y.; Russo, A.; Narayanan, N.
Show abstract
Voltage-gated Cav Ca2+ channels are critical for the development and mature function of the nervous system. Variants in the CACNA2D4 gene encoding the 2{delta}-4 auxiliary subunit of these channels are associated with neuropsychiatric and neurodevelopmental disorders. 2{delta}-4 is prominently expressed in the retina and is crucial for vision, but extra-retinal functions of 2{delta}-4 have not been investigated. Here, we sought to fill this gap by analyzing the behavioral phenotypes of 2{delta}-4 knockout (KO) mice. 2{delta}-4 KO mice (both males and females) exhibited significant impairments in prepulse inhibition that were unlikely to result from the modestly elevated auditory brainstem response thresholds. Whereas 2{delta}-4 KO mice of both sexes were hyperactive in various assays, only females showed impaired motor learning/coordination in the rotarod assay. Female but not male 2{delta}-4 KO mice exhibited anxiolytic and anti-depressive behaviors in the elevated plus maze and tail suspension tests, respectively. Our results reveal an unexpected role for 2{delta}-4 in cognitive and motor function and identify 2{delta}-4 KO mice as a novel model for studying the pathophysiology associated with CACNA2D4 variants.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Partial or complete loss of norepinephrine differentially alters contextual fear and catecholamine release dynamics in hippocampal CA1 94%
- S100a9 Attenuates Inflammation during Repeated Social Defeat Stress 93%
- Genetic tagging uncovers a robust, selective activation of the thalamic paraventricular nucleus by adverse experiences early in life 93%
Similar papers in this journal
- GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior 95%
- Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour 94%
- Impaired trigeminal control of ingestive behavior in the Prrxl1- / - mouse is associated with a lemniscal-biased orosensory deafferentation 94%
Similar papers in this journal
Similar papers in this journal
- Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia 96%
- Inhibition of mTOR signaling by genetic removal of p70 S6 Kinase 1 leads to anxiety-like disorders 93%
- Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia 92%
Similar papers in this journal
- Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility 95%
- Chronic sodium bromide treatment relieves autistic-like behavioral deficits in three mouse models of autism 94%
- GABAA and NMDA receptor density alterations and their behavioral correlates in the gestational methylazoxymethanol acetate model for schizophrenia 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.