The Streptococcus agalactiae R3 surface protein is encoded by sar5
Dragset, M. S.; Basson, A.; Olaisen, C.; Selvik, L.-K.; Lyng, R. V.; Lysvand, H.; Aas, C. G.; Afset, J. E.
Show abstract
Streptococcus agalactiae (a group B streptococcus; GBS) is an important human pathogen causing pneumonia, sepsis and meningitis in neonates, as well as infections in pregnant women, immunocompromised individuals, and the elderly. For the future control of GBS-inflicted disease, GBS surface exposed proteins are particularly relevant as they may act as antigens for vaccine development and/or as serosubtype markers in epidemiological settings. Even so, the genes encoding some of the surface proteins established as serosubtype markers by antibody-based methods are still unknown. Here, we identify sar5 as the gene encoding the R3 surface protein, a serosubtype marker of hitherto unknown genetic origin.
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