Reliable cell retention of mammalian suspension cells in microfluidic cultivation chambers
Schmitz, J.; Stute, B.; Taeuber, S.; Kohlheyer, D.; von Lieres, E.; Gruenberger, A.
Show abstract
We present a new microfluidic trapping concept to retain randomly moving suspension cells inside a cultivation chamber. In comparison to previously published complex multilayer structures, we achieve cell retention by a thin PDMS barrier, which can be easily integrated into various PDMS-based cultivation devices. Cell loss during cultivation is effectively prevented while diffusive media supply is still ensured.
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