Containment of a multi-index B.1.1.7 outbreak on a university campus through a genomically-informed public health response
Martin, E. T.; Lauring, A. S.; Montgomery, J. P.; Valesano, A. L.; Eisenberg, M. C.; Sheen, D.; Nord, J.; Ernst, R. D.; Mortenson, L. Y.; Valdez, R.; Niknafs, Y.; Conway, D.; Rifat, S. F.; Bagdasarian, N.; Lyon-Callo, S.; Collins, J.; Blakenship, H.; Soehnlen, M.; Marquez, J.
Show abstract
The first cluster of SARS-CoV-2 cases with lineage B.1.1.7 in the state of Michigan was identified through intensive university-led surveillance sampling and targeted sequencing. A collaborative investigation and response was conducted by the local and state health departments, and the campus and athletic medicine COVID-19 response teams, using S-gene target failure screening and rapid genomic sequencing to inform containment strategies. A total of 50 cases of B.1.1.7-lineage SARS-CoV-2 were identified in this outbreak, which was due to three coincident introductions of B.1.1.7-lineage SARS-CoV-2, all of which were genetically distinct from lineages which later circulated in the broader community. This investigation demonstrates the successful implementation of a genomically-informed outbreak response which can be extended to university campuses and other settings at high risk for rapid emergence of new variants.
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