Back
Top 0.4%
12.0%
#1
11.1%
Top 0.8%
9.4%
Top 0.6%
7.9%
Top 0.2%
6.5%
Top 0.4%
6.0%
#1
5.1%
Top 86%
3.9%
Top 66%
3.9%
Top 0.6%
2.0%
Top 36%
2.0%
Top 48%
2.0%
Top 6%
2.0%
Top 28%
1.6%
Top 9%
1.6%
Top 11%
1.4%
Top 5%
1.4%
Top 8%
1.2%
Top 15%
1.2%
Top 2%
1.2%
Top 0.3%
1.0%
Top 11%
1.0%
Top 7%
1.0%
Top 1%
1.0%
Top 34%
0.7%
Top 6%
0.7%
Top 3%
0.7%
GB0139, an inhaled small molecule inhibitor of galectin-3, in COVID-19 pneumonitis: a randomised, controlled, open-label, phase 2a experimental medicine trial of the safety, pharmacokinetics, and potential therapeutic value
2021-12-21
respiratory medicine
Title + abstract only
View on medRxiv
Show abstract
RationaleHigh galectin-3 levels predict poor outcomes in patients with COVID-19. Galectin-3 activates monocytes and macrophages which are directly implicated in COVID-19 immunopathology and the cytokine storm. GB0139 is a potent thiodigalactoside galectin-3 inhibitor and may reduce the severe effects of the disease. We report safety and pharmacokinetics and pharmacodynamics of the inhaled galectin-3 inhibitor, GB0139, and assess clinical outcomes and key systemic inflammatory biomarkers in hospi...
Predicted journal destinations
1
European Respiratory Journal
44 training papers
2
Thorax
29 training papers
3
BMJ Open Respiratory Research
32 training papers
4
ERJ Open Research
36 training papers
5
New England Journal of Medicine
49 training papers
6
American Journal of Respiratory and Critical Care Medicine
23 training papers
7
eClinicalMedicine
55 training papers
8
PLOS ONE
1737 training papers
9
Scientific Reports
701 training papers
10
Journal of Allergy and Clinical Immunology
15 training papers
11
Nature Communications
483 training papers
12
BMJ Open
553 training papers
13
Frontiers in Immunology
140 training papers
14
eLife
262 training papers
15
Open Forum Infectious Diseases
124 training papers
16
The Journal of Infectious Diseases
137 training papers
17
JCI Insight
63 training papers
18
iScience
74 training papers
19
Frontiers in Medicine
99 training papers
20
Frontiers in Pharmacology
27 training papers
21
The Lancet Respiratory Medicine
16 training papers
22
Journal of Medical Virology
95 training papers
23
Clinical Microbiology and Infection
54 training papers
24
Clinical Pharmacology & Therapeutics
19 training papers
25
BMC Medicine
155 training papers
26
Medicine
29 training papers
27
mBio
34 training papers