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Interpretable Visualization of Scientific Hypotheses in Literature-based Discovery

Tyagin, I.; Safro, I.

2021-11-02 bioinformatics
10.1101/2021.10.29.466471 bioRxiv
Show abstract

In this paper we present an approach for interpretable visualization of scientific hypotheses that is based on the idea of semantic concept interconnectivity, network-based and topic modeling methods. Our visualization approach has numerous adjustable parameters which provides the domain experts with additional flexibility in their decision making process. We also make use of the Unified Medical Language System metadata by integrating it directly into the resulting topics, and adding the variability into hypotheses resolution. To demonstrate the proposed approach in action, we deployed end-to-end hypothesis generation pipeline AGATHA, which was evaluated by BioCreative VII experts with COVID-19-related queries.

Matching journals

The top 6 journals account for 50% of the predicted probability mass.

50% of probability mass above

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.