White matter disruption as a cause or consequence of schizophrenia: A Mendelian randomization study
Jefsen, O. H.; Speed, M. S.; Friston, K. J.; Ostergaard, S. D.; Speed, D.
Show abstract
Brief abstractSchizophrenia is hypothesized to be caused by impaired functional integration in the brain, and this could hypothetically be caused by white matter disruptions, synaptic dysfunction, or both. Neuroimaging studies consistently show reduced fractional anisotropy, a measure of white matter integrity, in patients with schizophrenia. Using Mendelian randomization, we show that these white matter changes are likely to be the consequence of a primary synaptopathy in schizophrenia.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Evidence from imaging resilience genetics for a protective mechanism against schizophrenia in the ventral visual pathway 97%
- A 10-Year Longitudinal Study of Brain Cortical Thickness in People with First-Episode Psychosis using Normative Models 95%
- Exploring the relationship between schizophrenia and cardiovascular disease: A genetic correlation and multivariable Mendelian randomization study 95%
Similar papers in this journal
- Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis 95%
- Assessing the validity of a self-reported clinical diagnosis of schizophrenia 94%
- Neurobiology-based Cognitive Biotypes Using Multi-scale Intrinsic Connectivity Networks in Psychotic Disorders 94%
Similar papers in this journal
- Grey and white matter micro-structure is associated with polygenic risk for schizophrenia 96%
- Rare coding variants in schizophrenia-associated genes affect generalised cognition in the UK Biobank 95%
- Splitting Schizophrenia: Divergent Cognitive and Educational Outcomes Revealed by Genomic Structural Equation Modelling. 95%
Similar papers in this journal
- Connectivity patterns of task-specific brain networks allow individual prediction of cognitive symptom dimension of schizophrenia and link to molecular architecture 94%
- Schizotypy-related magnetization of cortex in healthy adolescence is co-located with expression of schizophrenia risk genes 94%
- Computational modelling of EEG and fMRI paradigms reveals a consistent loss of pyramidal cell synaptic gain in schizophrenia 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.