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Assessing the role of polygenic background on the penetrance of monogenic forms in Parkinson's disease.
2021-06-09
genetic and genomic medicine
Title + abstract only
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BackgroundSeveral rare and common variants are associated with Parkinsons disease. However, there is still an incomplete penetrance in the carriers of rare variants associated with Parkinsons disease. To address this issue, we investigated whether a PRS calculated from significant GWAS SNPs affects the penetrance of Parkinsons disease among carriers of rare monogenic variants in known Parkinsons disease genes and those with a family history. MethodsWe calculated the PRS based on common variants...
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